Description

Methyl 2-((1R,3R)-3-Amino-1-Hydroxy-4-Methylpentyl)Thiazole-4-Carboxylate Hydrochloride is a high-purity, chiral pharmaceutical intermediate of significant importance in modern synthetic chemistry. This compound is valued for its role as a key building block in the synthesis of complex, biologically active molecules, particularly in the development of new therapeutic agents. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel drugs, especially those targeting specific enzymatic pathways or requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Organic Synthesis Research: Serves as a versatile building block in academic and industrial R&D for constructing complex heterocyclic compounds and exploring new synthetic methodologies.
• Preclinical Drug Development: Used in the discovery and optimization phase for creating candidate drug molecules with specific stereochemistry.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	Methyl 2-((1R,3R)-3-Amino-1-Hydroxy-4-Methylpentyl)Thiazole-4-Carboxylate Hydrochloride
CAS No.	921927-91-5
Molecular Formula	C12H19N2O3S • HCl
Molecular Weight	308.81 g/mol (Free base: 271.35 g/mol)
Synonyms	(1R,3R)-Methyl 3-Amino-1-hydroxy-4-methylpentyl thiazole-4-carboxylate hydrochloride; (1R,3R)-3-Amino-1-hydroxy-4-methylpentyl thiazole-4-carboxylate methyl ester hydrochloride; Thiazole-4-carboxylic acid, 2-[(1R,3R)-3-amino-1-hydroxy-4-methylpentyl]-, methyl ester, hydrochloride; Methyl (1R,3R)-3-amino-1-hydroxy-4-methylpentyl thiazole-4-carboxylate HCl; Chiral thiazole carboxylate ester hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl 2-((1R,3R)-3-Amino-1-Hydroxy-4-Methylpentyl)Thiazole-4-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.