Description

1H-Pyrrolo[2,3-B]Pyridine-5-Carboxamide, 4-Chloro- is a high-purity organic intermediate of significant importance in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting kinase inhibition. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of kinase inhibitor drug candidates for oncology and inflammatory diseases.
• Chemical Biology Research: Used as a core scaffold for developing molecular probes to study biological pathways and protein functions.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Process Chemistry Development: Serves as a starting material for scaling up and optimizing synthetic routes for potential new drugs.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring specialized heterocyclic chemistry.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Carboxamide, 4-Chloro-
CAS No.	920966-13-8
Molecular Formula	C8H6ClN3O
Molecular Weight	195.61 g/mol
Synonyms	4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxamide; 4-Chloro-7-azaindole-5-carboxamide; 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid amide; 920966-13-8; 4-Chloro-5-carbamoyl-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-1H-7-azaindole-5-carboxamide
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-5-Carboxamide, 4-Chloro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.