Description

7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trimethylsilyl)-1H-Indole CAS NO 919119-70-3 is a highly functionalized indole derivative that serves as a critical advanced pharmaceutical intermediate (API) and a versatile Suzuki-Miyaura cross-coupling building block. Its molecular architecture, featuring both a protected boronic ester and a trimethylsilyl group, makes it indispensable for the efficient synthesis of complex heterocyclic compounds. This specialty chemical is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for developing novel drug candidates and high-value materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex indole-based active pharmaceutical ingredients (APIs) and drug candidates.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety enables efficient carbon-carbon bond formation with aryl/heteroaryl halides for constructing biaryl systems.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and other functional organic materials requiring precise molecular architecture.
• Agrochemical Synthesis: Intermediate for creating novel indole-containing herbicides, fungicides, and plant growth regulators.
• Chemical Biology & Medicinal Chemistry: Valuable probe for synthesizing chemical libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Functional Dye and Pigment Development: Serves as a precursor for synthesizing advanced colorants with specific electronic properties.

Basic Information

Product Name	7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trimethylsilyl)-1H-Indole
CAS No.	919119-70-3
Molecular Formula	C17H26BNO2Si
Molecular Weight	315.29 g/mol
Synonyms	2-(Trimethylsilyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trimethylsilyl)-1H-indole; 1H-Indole, 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trimethylsilyl)-; 2-TMS-7-Bpin-indole; 7-Bpin-2-TMS-indole; 7-(Pinacolboryl)-2-(trimethylsilyl)indole; 919119-70-3
EINECS	Contact for details

Quality Control

Our production of 7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trimethylsilyl)-1H-Indole adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical and advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.