Description

N,n-Diethyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-2-Carboxamide is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex carbon-carbon bonds. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly those targeting indole-based therapeutic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient and selective introduction of the 7-substituted indole moiety into complex molecular architectures.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize drug-like properties.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes from laboratory to pilot and commercial production.
• Agrochemical Research: Potential application in the synthesis of novel crop protection agents and herbicides.
• Material Science Precursor: Exploration into the creation of organic electronic materials and functional polymers.

Basic Information

Product Name	N,n-Diethyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-2-Carboxamide
CAS No.	919119-68-9
Molecular Formula	C19H27BN2O3
Molecular Weight	342.24 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N,N-diethyl-1H-indole-2-carboxamide; N,N-Diethyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxamide; 1H-Indole-2-carboxamide, N,N-diethyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 919119-68-9; 7-Pinacolatoboryl-N,N-diethyl-1H-indole-2-carboxamide; 7-BPin-N,N-diethyl-1H-indole-2-carboxamide
EINECS	Contact for details

Quality Control

Our N,n-Diethyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-2-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.