Description

Ethyl 2-Methyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-3-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heterobiaryl scaffolds. It is primarily sought by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly for oncology, CNS disorders, and inflammation.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, especially those containing indole or biaryl motifs.
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester group acts as a stable, air-tolerant handle for palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Medicinal Chemistry Research: Enables rapid analog synthesis and structure-activity relationship (SAR) studies during early-stage drug discovery.
• API Development: Used in process chemistry for scaling up the synthesis of target molecules under controlled GMP-like conditions.
• Agrochemical & Material Science: Potential applications in creating novel ligands, organic electronic materials, or bioactive agrochemicals.

Basic Information

Product Name	Ethyl 2-Methyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-3-Carboxylate
CAS No.	919119-66-7
Molecular Formula	C20H28BNO4
Molecular Weight	357.26 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-1H-indole-3-carboxylic acid ethyl ester; Ethyl 2-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-3-carboxylate; 2-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-3-carboxylic acid ethyl ester; 919119-66-7; 7-Pinacolatoboryl-2-methyl-1H-indole-3-carboxylic acid ethyl ester; Ethyl 2-methyl-7-(pinacolatoboryl)-1H-indole-3-carboxylate; 7-(Pinacolatoboryl)-2-methyl-1H-indole-3-carboxylic acid ethyl ester.
EINECS	Contact for details

Quality Control

Our Ethyl 2-Methyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.