Description

1H-Indole-2-Carboxylic Acid, 5-Methoxy-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester is a high-value, multi-functional boronic ester derivative of indole, serving as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in enabling efficient, precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and agrochemical development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity building blocks for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, serotonin receptor modulators, and other bioactive indole-based compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the indole scaffold imparts specific biological activity.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and conductive polymers, due to its electron-rich indole core and functional handle for polymerization.
• Chemical Biology & Proteomics: Serves as a versatile probe or linker in the development of activity-based protein profiling (ABPP) reagents and other biochemical tools.
• Academic & Contract Research: A vital reagent for methodology development in cross-coupling chemistry and the exploration of new synthetic routes to complex natural products.
• Scale-up Process Development: Supplied to process chemistry teams for route scouting, optimization, and pilot-scale production of target molecules.

Basic Information

Product Name	1H-Indole-2-Carboxylic Acid, 5-Methoxy-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester
CAS No.	919119-64-5
Molecular Formula	C20H28BNO6
Molecular Weight	389.25 g/mol
Synonyms	5-Methoxy-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylic acid ethyl ester; Ethyl 5-methoxy-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylate; 7-BPin-5-methoxy-1H-indole-2-carboxylic acid ethyl ester; 5-Methoxy-7-BPin-indole-2-carboxylic acid ethyl ester; Boronic ester indole intermediate; 919119-64-5; [919119-64-5]
EINECS	Contact for details

Quality Control

Every batch of our 1H-Indole-2-Carboxylic Acid, 5-Methoxy-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency, which are critical for reproducible results in sensitive cross-coupling reactions. Our products undergo rigorous analytical characterization using HPLC, NMR (1H, 13C, 11B), and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, we recommend storing the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after the original container has been opened. Ideal storage temperature is between 2°C and 8°C (refrigerated) for prolonged shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.