Description

Ethyl 5-Chloro-7 (4,4,5,5-Tetramethyl-1,3,2-Dioxaboryl) Indole-2-Carboxylate is a high-value, multi-functional boronic ester derivative of an indole scaffold, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and scalable routes to novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Research: Used in creating new active ingredients for herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Precursor for organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Synthesis: Versatile reagent for Suzuki-Miyaura cross-coupling to introduce the functionalized indole moiety into more complex molecular architectures.
• Academic & R&D: A valuable tool for methodological development and exploring new chemical space in university and industrial research laboratories.
• Ligand Synthesis: Can be utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	Ethyl 5-Chloro-7 (4,4,5,5-Tetramethyl-1,3,2-Dioxaboryl) Indole-2-Carboxylate
CAS No.	919119-63-4
Molecular Formula	C17H21BClNO4
Molecular Weight	349.62 g/mol
Synonyms	Ethyl 5-Chloro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylate; 5-Chloro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylic acid ethyl ester; 7-Boronic acid, 5-chloro-1H-indole-2-carboxylic acid ethyl ester, pinacol ester; 919119-63-4; Pinacol 5-Chloro-7-borono-1H-indole-2-carboxylate ethyl ester; 5-Chloro-7-pinacolatoboryl-1H-indole-2-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 5-Chloro-7 (4,4,5,5-Tetramethyl-1,3,2-Dioxaboryl) Indole-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.