Description

3-Bromo-1-[Tris(1-Methylethyl)Silyl]-1H-Pyrrolo[2,3-B]Pyridine is a high-value, organosilicon-protected heterocyclic building block designed for advanced synthetic chemistry. This compound matters because it provides a strategically functionalized pyrrolopyridine core, enabling precise derivatization in complex molecule construction. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, particularly in kinase inhibitor and other small-molecule drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its halogenated heterocyclic structure.
• Material Science: Serves as a specialized monomer or precursor for organic electronic materials and functional polymers.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille).
• Directed Functionalization: The silyl protecting group allows for regioselective further modification of the heterocyclic nitrogen.
• Academic & Contract Research: A valuable reagent for methodology development and library synthesis in academic and CRO laboratories.

Basic Information

Product Name	3-Bromo-1-[Tris(1-Methylethyl)Silyl]-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	918525-02-7
Molecular Formula	C17H27BrN2Si
Molecular Weight	367.40 g/mol
Synonyms	3-Bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-1-[tris(1-methylethyl)silyl]-; 3-Bromo-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; 3-Bromo-1-TIPS-1H-pyrrolo[2,3-b]pyridine; TIPS-protected 3-bromopyrrolopyridine; 918525-02-7; 3-Bromo-1-(tri-iso-propylsilyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-1-[Tris(1-Methylethyl)Silyl]-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full analytical data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.