Description

1H-Pyrrolo[2,3-B]Pyridine, 5-Methyl-1-[Tris(1-Methylethyl)Silyl]- is a high-purity, organosilicon-protected heterocyclic building block of significant importance in advanced organic synthesis. This compound is specifically engineered to provide a reactive nitrogen-containing core with a robust triisopropylsilyl (TIPS) protecting group, offering superior stability during complex multi-step reactions. It is a critical intermediate for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing novel active molecules targeting kinase inhibition and other biological pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used to develop new active ingredients for crop protection products, leveraging its heterocyclic scaffold.
• Material Science: Serves as a building block for creating specialized organic electronic materials and ligands for catalysis.
• Academic & R&D: Essential for methodological studies in organic chemistry, particularly in protecting group strategies and heterocyclic chemistry.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 5-Methyl-1-[Tris(1-Methylethyl)Silyl]-
CAS No.	918523-66-7
Molecular Formula	C17H28N2Si
Molecular Weight	288.50 g/mol
Synonyms	5-Methyl-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1-Triisopropylsilyl-5-methyl-1H-pyrrolo[2,3-b]pyridine; 5-Methyl-1-(triisopropylsilyl)-7-azaindole; 7-Azaindole, 5-methyl-1-(triisopropylsilyl)-; TIPS-5-Methyl-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 5-methyl-1-[(1,1-dimethylethyl)dimethylsilyl]- (related); 5-Methyl-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine, 5-Methyl-1-[Tris(1-Methylethyl)Silyl]- adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality systems are designed to support cGMP compliance for advanced intermediate applications, ensuring traceability and consistency for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.