Description

1H-Indazole, 5-Bromo-3-Iodo-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is a high-purity, multi-functionalized indazole derivative designed for advanced chemical synthesis. This compound is a critical building block for medicinal chemistry and pharmaceutical research, offering versatile reactivity for constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its reactive halogen sites and protected nitrogen.
• Agrochemical Development: Employed in the research and synthesis of new active ingredients for crop protection products.
• Chemical Biology Probes: Acts as a scaffold for developing molecular probes to study biological pathways and enzyme functions.
• Material Science: Potential building block for organic electronic materials and specialty polymers.
• Cross-Coupling Reactions: The bromo and iodo substituents make it an excellent substrate for palladium-catalyzed cross-coupling reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination.

Basic Information

Product Name	1H-Indazole, 5-Bromo-3-Iodo-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-
CAS No.	918440-14-9
Molecular Formula	C13H18BrIN2OSi
Molecular Weight	453.17 g/mol
Synonyms	5-Bromo-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole; 5-Bromo-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)indazole; 1-((2-(Trimethylsilyl)ethoxy)methyl)-5-bromo-3-iodo-1H-indazole; 5-Bromo-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole; 1H-Indazole, 5-bromo-3-iodo-1-[[2-(trimethylsilyl)ethoxy]methyl]-; 5-Bromo-3-iodo-1-SEM-indazole; Br,I-SEM-Indazole; SEM-Protected 5-Bromo-3-iodoindazole
EINECS	Contact for details

Quality Control

Our 1H-Indazole, 5-Bromo-3-Iodo-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.