Description

2-(2,2,2-Trifluoroethyl)Pyridine-5-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethylpyridine motifs.
• Suzuki-Miyaura Cross-Coupling: Essential reagent for forming carbon-carbon bonds between the pyridine ring and various aryl/heteroaryl halides, enabling library synthesis for drug discovery.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that leverage the biological activity of fluorinated pyridine derivatives.
• Material Science: Serves as a precursor for creating functionalized ligands, organic electronic materials, and metal-organic frameworks (MOFs).
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of molecular probes and tool compounds for target identification and validation.
• Process Chemistry & Scale-up: Supplied in development and commercial quantities for the optimization and manufacturing of final target molecules.

Basic Information

Product Name	2-(2,2,2-Trifluoroethyl)Pyridine-5-Boronic Acid Pinacol Ester
CAS No.	917969-86-9
Molecular Formula	C13H15BF3NO2
Molecular Weight	285.07 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethyl)pyridine; 2-(Trifluoroethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-(2,2,2-Trifluoroethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-(Trifluoroethyl)pyridine-5-boronic acid pinacol ester; Pyridine, 2-(2,2,2-trifluoroethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 917969-86-9
EINECS	Contact for details

Quality Control

Our 2-(2,2,2-Trifluoroethyl)Pyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive analytical data, including HPLC purity, NMR (1H, 13C, 19F, 11B), and mass spectrometry confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request and can support regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.