Description

tert-Butyl(3,5-Difluorophenoxy)Dimethylsilane is a specialized organosilicon reagent featuring a protected phenoxy group. This compound is valued for its role as a key synthetic intermediate and protecting group in advanced organic synthesis, particularly in the construction of complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that incorporate difluorophenoxy motifs.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in transition metal catalysis.
• Material Science Research: Employed in the surface modification of materials and the synthesis of silicon-containing polymers.
• Organic Synthesis Reagent: Functions as a versatile protecting group for phenols during multi-step synthetic sequences.
• Chemical Biology Probes: Used in the development of molecular probes and tags for biochemical research.

Basic Information

Product Name	tert-Butyl(3,5-Difluorophenoxy)Dimethylsilane
CAS No.	917827-99-7
Molecular Formula	C12H18F2OSi
Molecular Weight	244.36 g/mol
Synonyms	tert-Butyldimethyl(3,5-difluorophenoxy)silane; (3,5-Difluorophenoxy)(tert-butyl)dimethylsilane; tert-Butyldimethylsilyl 3,5-difluorophenyl ether; TBDMS 3,5-difluorophenyl ether; TBDMS-3,5-difluorophenoxide; Silane, tert-butyl(3,5-difluorophenoxy)dimethyl-; 3,5-Difluorophenol tert-butyldimethylsilyl ether
EINECS	Contact for details

Quality Control

Our tert-Butyl(3,5-Difluorophenoxy)Dimethylsilane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC, GC, and NMR results. A Certificate of Analysis (COA) is supplied with each batch to verify identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.