Description

trans-4-Cyclopentylamino-1,1-dioxo-tetrahydrothiophen-3-ol hydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is critical for the synthesis of novel therapeutic agents, particularly in the development of targeted enzyme inhibitors. It is primarily required by research institutions and pharmaceutical companies engaged in the discovery and process development of new chemical entities for various disease targets.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of proprietary drug candidates, especially those targeting specific enzymatic pathways.
• Protease Inhibitor Research: Used in the development of novel inhibitors for cysteine or serine proteases, given its sulfone and amino alcohol functional groups.
• Chemical Biology Probes: Serves as a scaffold for creating activity-based probes to study enzyme function and mechanism in biological systems.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization studies for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Libraries: A valuable input for generating focused compound libraries aimed at high-value biological targets in drug discovery programs.

Basic Information

Product Name	trans-4-Cyclopentylamino-1,1-dioxo-tetrahydrothiophen-3-ol Hydrochloride
CAS No.	916901-11-6
Molecular Formula	C9H16ClNO3S
Molecular Weight	253.75 g/mol
Synonyms	trans-4-(Cyclopentylamino)tetrahydro-1,1-dioxothiophen-3-ol hydrochloride; 3-Thiophenol, tetrahydro-4-[(cyclopentyl)amino]-1,1-dioxide, hydrochloride, (3R,4R)-rel-; Tetrahydrothiophene-3-ol, 4-(cyclopentylamino)-1,1-dioxide, hydrochloride, trans-; 916901-11-6; (3R,4R)-4-(Cyclopentylamino)tetrahydrothiophene-3-ol 1,1-Dioxide Hydrochloride
EINECS	Contact for details

Quality Control

Our trans-4-Cyclopentylamino-1,1-dioxo-tetrahydrothiophen-3-ol hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral methods for stereochemical confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.