Description

trans-4-Cyclopropylamino-1,1-Dioxo-Tetrahydrothiophen-3-Ol Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its sulfolane-derived structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and process chemistry optimization.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of proprietary drug candidates, especially those targeting central nervous system (CNS) disorders and other specialized therapeutic areas.
• Process Chemistry Research: Used in route scouting and optimization for the scalable production of complex target molecules in medicinal chemistry programs.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.
• Academic & Industrial R&D: Employed in exploratory research to investigate new chemical reactions and develop novel synthetic methodologies involving cyclopropylamine and sulfone functionalities.

Basic Information

Product Name	trans-4-Cyclopropylamino-1,1-Dioxo-Tetrahydrothiophen-3-Ol Hydrochloride
CAS No.	916901-09-2
Molecular Formula	C7H12ClNO3S
Molecular Weight	225.69 g/mol
Synonyms	trans-4-(Cyclopropylamino)-3-hydroxy-1,1-dioxo-tetrahydrothiophene hydrochloride; 3-Hydroxy-4-(cyclopropylamino)tetrahydrothiophene 1,1-dioxide hydrochloride; 4-Cyclopropylamino-3-hydroxytetrahydrothiophene-1,1-dioxide HCl; (3R,4S)-4-(Cyclopropylamino)tetrahydrothiophene-3-ol 1,1-dioxide hydrochloride (stereoisomer specific); CPATHD hydrochloride; Sulfolane derivative intermediate 916901-09-2
EINECS	Contact for details

Quality Control

Our trans-4-Cyclopropylamino-1,1-Dioxo-Tetrahydrothiophen-3-Ol Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate production. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% de (trans-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.