Description

trans-4-(Cyclopropylmethyl-Amino)-1,1-Dioxo-Tetrahydrothiophen-3-Ol Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents. The CAS number for this compound is 916901-08-1.

Application

This specialized intermediate serves as a key precursor in several high-value synthetic pathways.

• Pharmaceutical Intermediate: Primary use as a building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Active Pharmaceutical Ingredient (API) Development: Integral component in the multi-step synthesis of potential APIs, where its specific stereochemistry is crucial for biological activity.
• Medicinal Chemistry Research: Used in academic and industrial R&D labs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-Up: Serves as a defined starting material for developing and optimizing scalable, GMP-compliant manufacturing processes for new chemical entities.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	trans-4-(Cyclopropylmethyl-Amino)-1,1-Dioxo-Tetrahydrothiophen-3-Ol Hydrochloride
CAS No.	916901-08-1
Molecular Formula	C9H16ClNO3S
Molecular Weight	253.75 g/mol
Synonyms	trans-4-[(Cyclopropylmethyl)amino]tetrahydro-1,1-dioxothiophen-3-ol hydrochloride; 3-Thiophenol, tetrahydro-4-[(cyclopropylmethyl)amino]-, 1,1-dioxide, hydrochloride, (3R,4R)-rel-; Tetrahydrothiophene-3-ol derivative; 1,1-Dioxotetrahydrothiophene-3-ol hydrochloride derivative; CPMA-THT HCl; (3R,4R)-4-(Cyclopropylmethylamino)tetrahydrothiophene-3-ol 1,1-dioxide hydrochloride
EINECS	Contact for details

Quality Control

Our production of trans-4-(Cyclopropylmethyl-Amino)-1,1-Dioxo-Tetrahydrothiophen-3-Ol Hydrochloride adheres to stringent quality protocols suitable for pharmaceutical development. Each batch is manufactured under controlled conditions and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for all critical parameters are provided and can be tailored to meet client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.