Description

1-Boc-3-Chloroacetylindole CAS NO 916818-18-3 is a high-purity, protected indole derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its value lies in the dual functionality of the Boc-protected amine and the reactive chloroacetyl group, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides that leverage the indole scaffold.
• Organic Synthesis Reagent: Serves as a versatile precursor for introducing functionalized indole moieties into more complex molecular architectures.
• Peptidomimetics Research: Employed in the design and synthesis of peptide analogs and constrained scaffolds for medicinal chemistry.
• Material Science: Potential intermediate for creating specialty chemicals and functional organic materials.

Basic Information

Product Name	1-Boc-3-Chloroacetylindole
CAS No.	916818-18-3
Molecular Formula	C₁₅H₁₆ClNO₃
Molecular Weight	293.75 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-chloroacetylindole; tert-Butyl 3-(chloroacetyl)-1H-indole-1-carboxylate; 3-Chloroacetyl-1-Boc-indole; 1-Boc-3-(chloroacetyl)indole; 1-Boc-indole-3-glyoxyl chloride (common name); Boc-3-Chloroacetylindole; 1-N-Boc-3-chloroacetylindole
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Chloroacetylindole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically exceeding 97% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.