Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Methoxy-1-(Phenylsulfonyl)- is a high-purity, functionalized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile and critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its privileged scaffold.
• Agrochemical Synthesis: Serves as a building block for developing novel pesticides and herbicides with specific modes of action.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Material Science Research: Investigated as a precursor for organic electronic materials and advanced polymers.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects and scale-up activities.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Methoxy-1-(Phenylsulfonyl)-
CAS No.	916574-87-3
Molecular Formula	C14H12N2O3S
Molecular Weight	288.32 g/mol
Synonyms	4-Methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Benzenesulfonyl)-4-methoxy-1H-pyrrolo[2,3-b]pyridine; 4-Methoxy-1-tosyl-1H-pyrrolo[2,3-b]pyridine (common alias); 1H-Pyrrolo[2,3-b]pyridine, 4-methoxy-1-(phenylsulfonyl)-; N-(Phenylsulfonyl)-4-methoxy-7-azaindole; 4-Methoxy-7-azaindole-1-sulfonamide, N-phenyl-; 916574-87-3; 4-Methoxy-1H-pyrrolo[2,3-b]pyridine 1-sulfonic acid phenyl ester
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 4-Methoxy-1-(Phenylsulfonyl)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.