Description

1-[[2'-(Methoxycarbonyl)[1,1'-Biphenyl]-4-Yl]Methyl]-4-Methyl-2-Propyl-1H-Benzimidazole-6-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key synthetic precursor in the development of active pharmaceutical ingredients (APIs), particularly in the cardiovascular and metabolic disease therapeutic areas. It is primarily sought by pharmaceutical manufacturers, contract research organizations (CROs), and fine chemical synthesis laboratories engaged in process development and scale-up activities.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex drug molecules, especially sartans and related compounds.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the research, development, and commercial production of specific APIs targeting hypertension and other cardiovascular conditions.
• Process Chemistry & Scale-Up: Essential for process optimization, route scouting, and pilot-to-commercial scale manufacturing campaigns in fine chemical production.
• Reference Standard: Employed as a high-purity analytical standard for quality control (QC) and method validation in pharmaceutical analysis (HPLC, LC-MS).
• Chemical Research: Utilized in academic and industrial R&D for exploring new benzimidazole-based compounds and their biological activities.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	1-[[2'-(Methoxycarbonyl)[1,1'-Biphenyl]-4-Yl]Methyl]-4-Methyl-2-Propyl-1H-Benzimidazole-6-Carboxylic Acid Methyl Ester
CAS No.	916332-38-2
Molecular Formula	C30H30N2O4
Molecular Weight	482.57 g/mol
Synonyms	Methyl 1-[(2'-methoxycarbonylbiphenyl-4-yl)methyl]-4-methyl-2-propylbenzimidazole-6-carboxylate; Telmisartan Impurity; Telmisartan Intermediate; Telmisartan Methyl Ester Derivative; BIBR-277 Methyl Ester; 1-[(2'-Carbomethoxybiphenyl-4-yl)methyl]-4-methyl-2-propyl-1H-benzimidazole-6-carboxylic Acid Methyl Ester; 4'-[[4-Methyl-6-(methoxycarbonyl)-2-propyl-1H-benzimidazol-1-yl]methyl][1,1'-biphenyl]-2-carboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our 1-[[2'-(Methoxycarbonyl)[1,1'-Biphenyl]-4-Yl]Methyl]-4-Methyl-2-Propyl-1H-Benzimidazole-6-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer or regulatory requirements (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.