Description

5-(1H-Imidazol-2-Yl)-Thiophene-2-Carboxylic Acid is a high-value heterocyclic building block that combines imidazole and thiophene pharmacophores, making it a critical intermediate in advanced organic synthesis. Its unique structure is essential for constructing complex molecules with targeted biological activity, offering significant value in research and development. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, as well as by academic and contract research organizations engaged in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors, anti-inflammatory agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science & Organic Electronics: Serves as a building block for conjugated polymers and organic semiconductors due to the electron-rich thiophene and imidazole units.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) explorations to optimize potency and selectivity of lead compounds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and scale-up projects under cGMP or research-grade conditions.

Basic Information

Product Name	5-(1H-Imidazol-2-Yl)-Thiophene-2-Carboxylic Acid
CAS No.	915922-58-6
Molecular Formula	C8H6N2O2S
Molecular Weight	194.21 g/mol
Synonyms	2-Thiophenecarboxylic acid, 5-(1H-imidazol-2-yl)-; 5-(1H-Imidazol-2-yl)thiophene-2-carboxylic acid; 5-(2-Imidazolyl)thiophene-2-carboxylic acid; 2-(2-Carboxythiophen-5-yl)-1H-imidazole; 5-(Imidazol-2-yl)thiophene-2-carboxylic acid; Thiophene-2-carboxylic acid, 5-(1H-imidazol-2-yl)-; 915922-58-6
EINECS	Contact for details

Quality Control

Our production of 5-(1H-Imidazol-2-Yl)-Thiophene-2-Carboxylic Acid adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques, including HPLC, NMR, and MS, for comprehensive identity confirmation and purity verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key specifications. For projects requiring specific grade qualifications (e.g., >98% or >99% purity), please contact our technical team to discuss custom synthesis and tailored QC protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.