Description

Cyclopropyl-(1,1-Dioxo-Tetrahydrothiophen-3-Yl)-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of proprietary drug candidates, especially those targeting central nervous system (CNS) disorders and other specialized therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• Process Chemistry Development: Serves as a standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Utilized in the development of tool compounds for investigating biological pathways and target validation.
• Custom Synthesis: A foundational component for contract synthesis of complex molecules for preclinical and clinical trial material supply.

Basic Information

Product Name	Cyclopropyl-(1,1-Dioxo-Tetrahydrothiophen-3-Yl)-Amine Hydrochloride
CAS No.	915402-17-4
Molecular Formula	C8H14ClNO2S
Molecular Weight	223.72 g/mol
Synonyms	3-(Cyclopropylamino)thiolane 1,1-dioxide hydrochloride; Cyclopropyl-(1,1-dioxo-tetrahydro-3-thienyl)amine hydrochloride; 1,1-Dioxo-tetrahydrothiophen-3-yl-cyclopropyl-amine hydrochloride; 3-(Cyclopropylamino)tetrahydrothiophene 1,1-dioxide HCl; Tetrahydrothiophene-3-amine, N-cyclopropyl-, 1,1-dioxide, hydrochloride; Cyclopropyl(1,1-dioxothiolan-3-yl)amine hydrochloride
EINECS	Contact for details

Quality Control

Our Cyclopropyl-(1,1-Dioxo-Tetrahydrothiophen-3-Yl)-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure full traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.