Description

3-Bromo-5-Nitroindole-1-Carboxylic Acid tert-Butyl Ester is a high-value, multi-functional indole derivative serving as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring a versatile, protected intermediate to construct complex heterocyclic scaffolds. It is primarily utilized in pharmaceutical R&D for the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel indole-based active pharmaceutical ingredients (APIs) and investigational new drugs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators with indole core structures.
• Material Science: Building block for creating specialized organic electronic materials and functional dyes.
• Academic & Contract Research: Essential reagent for method development and exploring new synthetic pathways in heterocyclic chemistry.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Chemical Biology Probes: Used to create molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	3-Bromo-5-Nitroindole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	914349-31-8
Molecular Formula	C13H13BrN2O4
Molecular Weight	341.16 g/mol
Synonyms	tert-Butyl 3-bromo-5-nitro-1H-indole-1-carboxylate; 1H-Indole-1-carboxylic acid, 3-bromo-5-nitro-, 1,1-dimethylethyl ester; 3-Bromo-5-nitroindole-1-carboxylic acid 1,1-dimethylethyl ester; 3-Bromo-5-nitro-1H-indole-1-carboxylic acid tert-butyl ester; 3-Br-5-NO2-indole-1-COOtBu; Boc-3-Bromo-5-Nitroindole; 914349-31-8
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Nitroindole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.