Description

6-Benzyloxy-3-Iodoindole-1-Carboxylic Acid tert-Butyl Ester is a high-value, multi-functional indole derivative designed for advanced organic synthesis. This compound serves as a critical protected intermediate, enabling the precise construction of complex heterocyclic scaffolds in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of indole-based drug candidates targeting various therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its versatile benzyloxy and iodo functional groups.
• Peptidomimetic Synthesis: Serves as a protected precursor for incorporating modified tryptophan analogs into peptide chains.
• Agrochemical Development: Employed in the research and synthesis of novel crop protection agents with indole core structures.
• Material Science Precursor: Potential use in the development of organic electronic materials and functional dyes.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).

Basic Information

Product Name	6-Benzyloxy-3-Iodoindole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	914349-30-7
Molecular Formula	C20H20INO3
Molecular Weight	449.28 g/mol
Synonyms	tert-Butyl 6-(benzyloxy)-3-iodo-1H-indole-1-carboxylate; 1H-Indole-1-carboxylic acid, 6-(phenylmethoxy)-3-iodo-, 1,1-dimethylethyl ester; 6-Benzyloxy-3-iodoindole-1-carboxylic acid tert-butyl ester; 3-Iodo-6-benzyloxyindole-1-carboxylic acid tert-butyl ester; Boc-6-BnO-3-Iodoindole; N-Boc-6-benzyloxy-3-iodoindole
EINECS	Contact for details

Quality Control

Our 6-Benzyloxy-3-Iodoindole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.