Description

tert-Butyl 4-(Benzyloxy)-3-Iodo-1H-Indole-1-Carboxylate, 4-(Benzyloxy)-1-(tert-Butoxycarbonyl)-3-Iodo-1H-Indole CAS NO 914349-27-2 is a high-purity, protected indole derivative featuring both a benzyloxy group and an iodine atom at strategic positions on the aromatic ring. This compound is a critical synthetic intermediate for constructing complex heterocyclic molecules, particularly in pharmaceutical research and development. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic research laboratories engaged in medicinal chemistry and the synthesis of novel bioactive compounds.

Application

This versatile iodinated indole building block is designed for advanced synthetic applications, including:

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly those targeting neurological disorders and oncology.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization through further functionalization via cross-coupling reactions.
• Palladium-Catalyzed Cross-Coupling: The iodine atom serves as an excellent handle for Suzuki, Stille, and Sonogashira reactions to introduce diverse aryl, alkenyl, or alkynyl groups.
• Peptidomimetic Synthesis: Used in the construction of indole-based scaffolds that mimic peptide structures for drug discovery.
• Chemical Biology Probes: Acts as a starting material for creating labeled compounds or probes for biological target identification.
• Material Science Research: Potential building block for organic electronic materials due to the indole core's electron-rich properties.

Basic Information

Product Name	tert-Butyl 4-(Benzyloxy)-3-Iodo-1H-Indole-1-Carboxylate, 4-(Benzyloxy)-1-(tert-Butoxycarbonyl)-3-Iodo-1H-Indole
CAS No.	914349-27-2
Molecular Formula	C20H20INO3
Molecular Weight	449.28 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 4-(benzyloxy)-3-iodo-, 1,1-dimethylethyl ester; 4-(Benzyloxy)-3-iodo-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(benzyloxy)-3-iodo-1H-indole-1-carboxylate; 4-(Benzyloxy)-1-Boc-3-iodoindole; 3-Iodo-4-benzyloxy-1H-indole-1-carboxylic acid tert-butyl ester; Boc-4-OBn-3-I-indole; 1-Boc-4-OBn-3-iodoindole; 4-O-Benzyl-3-iodo-1H-indole-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Benzyloxy)-3-Iodo-1H-Indole-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material is suitable for advanced research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.