Description

3-Iodo-5-Methyl-1H-Indole-1-Carboxylic Acid tert-Butyl Ester is a high-value, functionalized indole derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its molecular architecture, featuring a halogenated indole core protected by a tert-butyl ester, makes it indispensable for constructing complex heterocyclic frameworks. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for applications in medicinal chemistry, process development, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology and CNS (Central Nervous System) research.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a precursor for organic electronic materials and functional dyes due to its conjugated indole system.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies and the introduction of iodine for further cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Process Chemistry: Utilized in route scouting and scale-up processes for the production of active pharmaceutical ingredients (APIs).
• Academic Research: A valuable reagent for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	3-Iodo-5-Methyl-1H-Indole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	914349-25-0
Molecular Formula	C14H16INO2
Molecular Weight	357.19 g/mol
Synonyms	tert-Butyl 3-iodo-5-methyl-1H-indole-1-carboxylate; 1H-Indole-1-carboxylic acid, 3-iodo-5-methyl-, 1,1-dimethylethyl ester; 3-Iodo-5-methylindole-1-carboxylic acid tert-butyl ester; 914349-25-0; 1-(tert-Butoxycarbonyl)-3-iodo-5-methylindole; BOC-3-Iodo-5-methylindole
EINECS	Contact for details

Quality Control

Every batch of 3-Iodo-5-Methyl-1H-Indole-1-Carboxylic Acid tert-Butyl Ester is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for research chemicals. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and meet the stringent requirements of our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.