Description

1-Boc-3-Bromo-5-Methylindole is a high-purity, protected indole derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators that require functionalized indole scaffolds.
• Material Science: Serves as a monomer or functional unit in the creation of organic semiconductors, dyes, and photoresponsive polymers.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development, cross-coupling reactions, and heterocyclic chemistry studies.
• Peptidomimetics & PROTACs: The protected amine and halogenated aromatic ring make it suitable for constructing peptide mimics and proteolysis-targeting chimeras (PROTACs).
• Scale-Up Process Development: Provides a reliable, high-quality starting material for optimizing synthetic routes from milligram to kilogram scale.

Basic Information

Item	Details
Product Name	1-Boc-3-Bromo-5-Methylindole
CAS No.	914349-24-9
Molecular Formula	C₁₄H₁₆BrNO₂
Molecular Weight	310.19 g/mol
Synonyms	tert-Butyl 3-bromo-5-methyl-1H-indole-1-carboxylate; 3-Bromo-5-methyl-1H-indole-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-bromo-5-methylindole; N-Boc-3-bromo-5-methylindole; Boc-3-Br-5-Me-indole; 3-Bromo-5-methyl-N-Boc-indole; 914349-24-9; tert-Butyl (3-bromo-5-methyl-1H-indol-1-yl)carboxylate
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Bromo-5-Methylindole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.