Description

1-Boc-4-Hydroxy-3-Hydroxymethylindole is a high-purity, protected indole derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its value lies in the orthogonal protection of the indole nitrogen and the presence of functionalizable hydroxyl groups, enabling precise and complex molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that leverage the indole scaffold.
• Peptidomimetics & Bioconjugation: The hydroxymethyl group provides a handle for linking to peptides, polymers, or other molecular entities in drug delivery systems.
• Material Science Precursor: Serves as a monomer or functional unit in the synthesis of specialized polymers and organic electronic materials.
• Academic & R&D Laboratories: A versatile reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-Boc-4-Hydroxy-3-Hydroxymethylindole
CAS No.	914349-12-5
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-hydroxy-3-(hydroxymethyl)indole; tert-Butyl 4-hydroxy-3-(hydroxymethyl)-1H-indole-1-carboxylate; 3-Hydroxymethyl-4-hydroxyindole-1-carboxylic acid tert-butyl ester; 1-Boc-4-hydroxyindole-3-methanol; Boc-protected 4-hydroxy-3-hydroxymethylindole; 914349-12-5; 1-Boc-4-OH-3-CH2OH-indole
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Hydroxy-3-Hydroxymethylindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high standards, such as cGMP development and research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.