Description

3-Formyl-5-Nitroindole-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a versatile indole scaffold with formyl and nitro functional groups. This compound is a critical building block in medicinal chemistry, enabling the synthesis of complex molecules for drug discovery and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the creation of novel therapeutic agents, particularly in oncology and CNS research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex indole-based drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Oncology Drug Development: Serves as a scaffold for creating potential kinase inhibitors and other targeted cancer therapies.
• Chemical Synthesis: Utilized in multi-step organic synthesis for introducing formyl and nitro substituents onto the indole core for further functionalization.
• Academic & Contract Research: Employed in university laboratories and CROs (Contract Research Organizations) for exploratory research and custom synthesis projects.

Basic Information

Product Name	3-Formyl-5-Nitroindole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	914349-06-7
Molecular Formula	C14H14N2O5
Molecular Weight	290.27 g/mol
Synonyms	1-Boc-3-formyl-5-nitroindole; tert-Butyl 3-formyl-5-nitro-1H-indole-1-carboxylate; 5-Nitro-1H-indole-1-carboxylic acid, 3-formyl-, 1,1-dimethylethyl ester; 3-Formyl-5-nitro-1H-indole-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-formyl-5-nitroindole; Boc-3-formyl-5-nitroindole; 914349-06-7
EINECS	Contact for details

Quality Control

Our 3-Formyl-5-Nitroindole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.