Description

1-Boc-4-Bromo-3-Hydroxymethylindole is a versatile and highly functionalized indole derivative, serving as a critical protected intermediate in advanced organic synthesis. Its value lies in the strategic placement of reactive sites—the bromo and hydroxymethyl groups—which allow for selective functionalization, making it indispensable for constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly those targeting neurological disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a precursor for functional polymers and advanced organic electronic materials.
• Peptidomimetics & Bioconjugation: Facilitates the creation of indole-based peptide analogs and linker molecules for bioconjugation strategies.
• Academic & R&D Laboratories: Employed in methodological studies and as a starting material for novel heterocyclic compound libraries.
• Scale-up Process Chemistry: Suitable for optimization and kilogram-scale production under GMP-like conditions for clinical trial material supply.

Basic Information

Product Name	1-Boc-4-Bromo-3-Hydroxymethylindole
CAS No.	914349-05-6
Molecular Formula	C₁₄H₁₆BrNO₃
Molecular Weight	326.19 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-bromo-3-(hydroxymethyl)indole; 4-Bromo-3-(hydroxymethyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-bromo-3-(hydroxymethyl)-1H-indole-1-carboxylate; 1-Boc-4-bromoindole-3-methanol; Boc-4-Br-3-CH2OH-indole; 914349-05-6; 4-Bromo-1-Boc-3-hydroxymethylindole
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Bromo-3-Hydroxymethylindole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring material that meets stringent internal standards or aligns with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.