Description

1-Boc-4-Chloro-3-Formylindole is a high-purity, multi-functional indole derivative serving as a critical advanced intermediate in organic synthesis. Its value lies in the strategic protection of the indole nitrogen by the Boc (tert-butoxycarbonyl) group and the presence of reactive chloro and formyl substituents, enabling precise and sequential functionalization. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex heterocyclic scaffolds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in developing new generation herbicides and fungicides that leverage the indole core's bioactivity.
• Material Science: Serves as a precursor for functionalized organic molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry due to its reactive aldehyde group.
• Academic & R&D: A versatile reagent for methodological studies in heterocyclic and cross-coupling chemistry.

Basic Information

Product Name	1-Boc-4-Chloro-3-Formylindole
CAS No.	914349-00-1
Molecular Formula	C₁₄H₁₄ClNO₃
Molecular Weight	279.72 g/mol
Synonyms	1-[(tert-Butoxy)carbonyl]-4-chloro-1H-indole-3-carboxaldehyde; 4-Chloro-3-formyl-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 4-chloro-3-formyl-1H-indole-1-carboxylate; 1-Boc-4-chloroindole-3-carboxaldehyde; 4-Chloro-1H-indole-3-carboxaldehyde, 1-Boc protected; Boc-4-Cl-3-CHO-indole; 914349-00-1
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Chloro-3-Formylindole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for research and advanced synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality management system is designed to support regulatory requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.