Description

3-Amino-5-Carboxybenzeneboronic Acid, n-Boc Protected 98 is a high-purity, protected boronic acid derivative essential for advanced organic synthesis. This compound is a critical building block in modern medicinal chemistry, particularly for the construction of complex molecules via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, especially those containing biaryl or heterobiaryl motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for creating carbon-carbon bonds under mild conditions.
• Protease Inhibitor Research: Used in the development of inhibitors targeting various proteases, where the boronic acid moiety acts as a pharmacophore.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes for studying enzyme function and mechanism.
• Material Science Precursor: Can be utilized in the preparation of organic electronic materials and metal-organic frameworks (MOFs).
• Agrochemical Synthesis: Intermediate in the research and development of novel herbicides and fungicides.

Basic Information

Product Name	3-Amino-5-Carboxybenzeneboronic Acid, n-Boc Protected 98
CAS No.	913835-72-0
Molecular Formula	C₁₂H₁₆BNO₆
Molecular Weight	281.07 g/mol
Synonyms	3-((tert-Butoxycarbonyl)amino)-5-boronobenzoic Acid; 3-(Boc-amino)-5-boronobenzoic Acid; 3-Amino-5-boronobenzoic Acid tert-Butyl Carbamate; 3-Boc-amino-5-carboxyphenylboronic Acid; 5-Carboxy-3-((tert-butoxycarbonyl)amino)benzeneboronic Acid; tert-Butyl N-[3-borono-5-(carboxy)phenyl]carbamate; Boronic acid, B-[3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-carboxyphenyl]-
EINECS	Contact for details

Quality Control

Our 3-Amino-5-Carboxybenzeneboronic Acid, n-Boc Protected 98 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure a purity of ≥98% and confirm identity. Certificates of Analysis (COA) with full batch traceability are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.