Description

1-(tert-Butyldimethylsilyl)-1H-Indol-5-Ylboronic Acid 97 is a high-purity, protected indole boronic acid derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient, selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop new active ingredients and functional molecules. The product is supplied with a minimum purity of 97%, ensuring reliable performance in sensitive applications.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in constructing indole-based scaffolds common in CNS and oncology therapeutics.
• Agrochemical Research: Used in creating new active ingredients for crop protection agents through targeted cross-coupling methodologies.
• Material Science: Serves as a precursor in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Synthesis: Enables the efficient introduction of the 5-indolyl moiety into complex molecules under mild, palladium-catalyzed conditions.
• Library Synthesis: Ideal for parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.
• Academic Research: A valuable reagent for methodological development in organic synthesis and catalysis studies at universities and R&D institutes.

Basic Information

Product Name	1-(tert-Butyldimethylsilyl)-1H-Indol-5-Ylboronic Acid 97
CAS No.	913835-68-4
Molecular Formula	C₁₄H₂₂BNO₂Si
Molecular Weight	275.23 g/mol
Synonyms	5-Borono-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indole; 1-(tert-Butyldimethylsilyl)-1H-indole-5-boronic acid; 1H-Indole-5-boronic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-; 1-TBDMS-indole-5-boronic acid; 1-(tert-Butyldimethylsilyl)indol-5-ylboronic acid; 5-Boron-1-TBDMS-indole; N-TBDMS-5-indolylboronic acid; 913835-68-4
EINECS	Contact for details

Quality Control

Our 1-(tert-Butyldimethylsilyl)-1H-Indol-5-Ylboronic Acid 97 is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the specified 97% minimum purity and consistent performance in cross-coupling reactions. Certificates of Analysis (COA) detailing all test results are available upon request. Our quality system is designed to support cGMP and ISO standards for traceability and reliability, which is critical for pharmaceutical and advanced material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. For long-term storage, desiccants are recommended. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.