Description

Cyclopenta[C]Pyrrole-2(1H)-Carboxylic Acid, Hexahydro-4-Hydroxy-, 1,1-Dimethylethyl Ester, (3Ar,4R,6As)-Rel- is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined bicyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and complex generics.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Drug Discovery & Medicinal Chemistry: Used in research for constructing complex heterocyclic cores in lead optimization and candidate development.
• Process Chemistry & Scale-Up: Serves as a critical starting material or intermediate in the development of scalable, GMP-compliant synthetic routes.
• Synthesis of Biologically Active Compounds: Employed in creating molecules with potential activity in central nervous system (CNS), metabolic, or anti-infective therapeutic areas.
• Asymmetric Synthesis: Utilized in stereoselective reactions due to its defined stereocenters, enabling the production of enantiomerically pure targets.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects requiring high chemical and isomeric purity.

Basic Information

Product Name	Cyclopenta[C]Pyrrole-2(1H)-Carboxylic Acid, Hexahydro-4-Hydroxy-, 1,1-Dimethylethyl Ester, (3Ar,4R,6As)-Rel-
CAS No.	913575-10-7
Molecular Formula	C12H19NO3
Molecular Weight	225.28 g/mol
Synonyms	rel-(3aR,4R,6aS)-Hexahydro-4-hydroxycyclopenta[c]pyrrole-2(1H)-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl (3aR,4R,6aS)-hexahydro-4-hydroxy-1H-cyclopenta[c]pyrrole-2-carboxylate; (3aR,4R,6aS)-tert-Butyl 4-hydroxyhexahydro-1H-cyclopenta[c]pyrrole-2(3H)-carboxylate; Bicyclic Proline Derivative; Hydroxylated Cyclopentapyrrolidine Carboxylate Ester; Advanced Chiral Pyrrolidine Intermediate; tert-Butyl ester of hexahydro-4-hydroxycyclopenta[c]pyrrole-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We employ state-of-the-art analytical techniques including HPLC, GC, Chiral HPLC, and NMR to verify identity and meet stringent customer specifications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.