Description

1H-Indole-1-Carboxylic Acid, 2-Borono-5-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, 1-(1,1-Dimethylethyl) Ester is a sophisticated boronic acid ester derivative of indole, designed as a key synthetic intermediate for advanced organic transformations. This compound matters for its role in facilitating complex carbon-carbon bond formation, particularly in the synthesis of novel pharmaceutical candidates and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries engaged in medicinal chemistry and catalyst development.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical, protected boronic acid ester reagent for constructing biaryl and heterobiaryl structures central to drug discovery.
• Medicinal Chemistry & Drug Discovery: Used as a versatile building block for the synthesis of indole-based drug candidates targeting various therapeutic areas.
• Agrochemical Intermediate: Employed in the research and development of novel active ingredients with complex heterocyclic architectures.
• Material Science Research: Acts as a precursor for creating organic electronic materials, ligands for catalysis, and advanced polymers.
• Process Chemistry Development: Utilized in scaling up synthetic routes for active pharmaceutical ingredients (APIs) requiring specific indole boronate intermediates.
• Academic & Contract Research: A valuable tool for methodological development in organic synthesis and catalysis research.

Basic Information

Product Name	1H-Indole-1-Carboxylic Acid, 2-Borono-5-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, 1-(1,1-Dimethyl) Ester
CAS No.	913388-66-6
Molecular Formula	C19H27BN2O5
Molecular Weight	374.24 g/mol
Synonyms	5-[(tert-Butoxycarbonyl)amino]-1H-indole-2-boronic acid 1-(tert-butyl) ester; 2-Borono-5-[(tert-butoxycarbonyl)amino]-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 5-((tert-butoxycarbonyl)amino)-1H-indole-2-boronate; Boc-protected 2-borono-5-aminoindole tert-butyl ester; 5-(Boc-amino)indole-2-boronic acid tert-butyl ester; Indole-2-boronic acid ester, Boc-protected; 913388-66-6; tert-Butyl 5-((tert-butoxycarbonyl)amino)-1H-indole-2-boronic acid ester
EINECS	Contact for details

Quality Control

Every batch of our 1H-Indole-1-Carboxylic Acid, 2-Borono-5-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, 1-(1,1-Dimethylethyl) Ester undergoes rigorous analytical testing to ensure high purity and consistency for sensitive synthetic applications. We adhere to strict in-house quality standards, with testing typically including HPLC for purity, NMR for structural confirmation, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation, especially after opening the original container. Ideal storage temperature is between 2°C and 8°C (refrigerated) for extended stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.