Description

1-(4-(Trifluoromethyl)Phenyl)Indolin-2-One is a high-value pharmaceutical intermediate and organic building block characterized by its indolinone core and trifluoromethylphenyl substituent. This molecular architecture is critical for imparting desirable metabolic stability and lipophilicity in advanced drug discovery and development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel bioactive compounds, particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of small molecule drugs targeting various disease pathways.
• Kinase Inhibitor Precursor: Used in the synthesis of potential kinase inhibitors for oncology research.
• Chemical Reference Standard: Serves as an analytical standard for quality control and method development in API manufacturing.
• Organic Synthesis Building Block: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Agrochemical Research: Investigated as an intermediate for developing novel crop protection agents.
• Material Science Research: Explored as a monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	1-(4-(Trifluoromethyl)Phenyl)Indolin-2-One
CAS No.	913382-56-6
Molecular Formula	C15H10F3NO
Molecular Weight	277.24 g/mol
Synonyms	1-[4-(Trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-2-one; 1-[4-(Trifluoromethyl)phenyl]indolin-2-one; 2-Indolinone, 1-[4-(trifluoromethyl)phenyl]-; 913382-56-6; 1-(4-Trifluoromethylphenyl)indolin-2-one; 1-(p-Trifluoromethylphenyl)indolin-2-one
EINECS	Contact for details

Quality Control

Our 1-(4-(Trifluoromethyl)Phenyl)Indolin-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.