Description

1-(7-Bromo-6-Nitro-3,4-Dihydroisoquinolin-2(1H)-)-2,2,2-Trifluoroethanone is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated and nitrated isoquinoline scaffold. This compound is of significant value in medicinal chemistry for the synthesis of novel drug candidates, particularly those targeting complex disease pathways. It is primarily sought by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of potential active pharmaceutical ingredients (APIs) for oncology, neurology, and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop novel drug-like molecules.
• Chemical Biology Probes: Acts as a precursor for creating specialized probes to study enzyme function or biological pathways.
• Agrochemical Research: Employed in the discovery and development of new crop protection agents due to its bioactive heterocyclic structure.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.
• Custom Synthesis: A key starting material for contract manufacturers offering bespoke chemical synthesis services.

Basic Information

Product Name	1-(7-Bromo-6-Nitro-3,4-Dihydroisoquinolin-2(1H)-)-2,2,2-Trifluoroethanone
CAS No.	912846-87-8
Molecular Formula	C₁₁H₈BrF₃N₂O₃
Molecular Weight	353.10 g/mol
Synonyms	2,2,2-Trifluoro-1-(7-bromo-6-nitro-1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one; 1-(7-Bromo-6-nitro-3,4-dihydro-2(1H)-isoquinolinyl)-2,2,2-trifluoroethanone; 7-Bromo-6-nitro-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline; 2-(Trifluoroacetyl)-7-bromo-6-nitro-1,2,3,4-tetrahydroisoquinoline; 912846-87-8; TFABNIQ; Bromo-nitro-tetrahydroisoquinoline trifluoroacetyl derivative.
EINECS	Contact for details

Quality Control

Our 1-(7-Bromo-6-Nitro-3,4-Dihydroisoquinolin-2(1H)-)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced intermediate production and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.