Description

tert-Butyl 6-Amino-7-Fluoro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a fluorine substituent on its isoquinoline core structure. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with enhanced metabolic stability and binding affinity. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of oncology and central nervous system (CNS) disorders.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical entities.
• Proteolysis Targeting Chimera (PROTAC) Development: The amine and fluorine groups make it a valuable component for constructing linkers and warheads in targeted protein degradation therapeutics.
• Kinase Inhibitor Precursor: Employed in the synthesis of potent and selective kinase inhibitors for cancer therapy.
• Fluorinated Compound Library Synthesis: The fluorine atom provides desirable pharmacokinetic properties, making it a sought-after fragment for combinatorial chemistry and library generation.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production of clinical trial materials.

Basic Information

Item	Details
Product Name	tert-Butyl 6-Amino-7-Fluoro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	912846-68-5
Molecular Formula	C14H19FN2O2
Molecular Weight	266.31 g/mol
Synonyms	6-Amino-7-fluoro-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 6-amino-7-fluoro-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 2(1H)-Isoquinolinecarboxylic acid, 6-amino-7-fluoro-3,4-dihydro-, 1,1-dimethylethyl ester; 6-Amino-7-fluoro-3,4-dihydro-2(1H)-isoquinolinecarboxylic acid tert-butyl ester; Boc-6-Amino-7-fluoro-THIQ; 7-Fluoro-6-amino-THIQ-Boc
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Amino-7-Fluoro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.