Description

tert-Butyl 7-Fluoro-6-Nitro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a nitro-fluoro substituted isoquinoline scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex bioactive molecules and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Kinase Inhibitor Synthesis: The fluoronitro-substituted isoquinoline structure is valuable for constructing potential kinase inhibitors.
• Chemical Biology Probes: Used to develop tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 7-Fluoro-6-Nitro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	912846-67-4
Molecular Formula	C₁₄H₁₇FN₂O₄
Molecular Weight	296.30 g/mol
Synonyms	2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-7-fluoro-6-nitro-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 7-fluoro-6-nitro-3,4-dihydro-2(1H)-isoquinolinecarboxylate; tert-Butyl 7-fluoro-6-nitro-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 7-Fluoro-6-nitro-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; Boc-7-Fluoro-6-Nitro-Tic-OH tert-butyl ester; 912846-67-4
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Fluoro-6-Nitro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and material can be supplied under cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.