Description

7-Fluoro-6-Nitro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 912846-66-3. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), offering a strategic advantage for research and development in medicinal chemistry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Serves as a versatile scaffold for constructing complex heterocyclic compounds and fused ring systems.
• Academic & Institutional Research: Employed in university and institutional labs for studying synthetic methodologies and reaction mechanisms.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and non-commercial API batches.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	7-Fluoro-6-Nitro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	912846-66-3
Molecular Formula	C9H10ClFN2O2
Molecular Weight	232.64 g/mol
Synonyms	7-Fluoro-6-nitro-1,2,3,4-tetrahydroisoquinoline HCl; 1,2,3,4-Tetrahydro-7-fluoro-6-nitroisoquinoline hydrochloride; 6-Nitro-7-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride; 7-Fluoro-6-nitro-3,4-dihydro-1H-isoquinoline hydrochloride; 7-Fluoro-6-nitro-1,2,3,4-tetrahydroisoquinoline monohydrochloride; 912846-66-3; FNTIQ HCl
EINECS	Contact for details

Quality Control

Our 7-Fluoro-6-Nitro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support our clients with full analytical traceability and can provide material to meet specific research or development-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.