Description

Gabapentin Enacarbil Sodium Salt is the water-soluble sodium salt of gabapentin enacarbil, a prodrug of the widely used anticonvulsant and analgesic gabapentin. This chemical form is specifically engineered to enhance bioavailability and provide a more consistent pharmacokinetic profile, making it a critical advanced intermediate in modern pharmaceutical development. It is primarily utilized by pharmaceutical R&D departments and manufacturers for the formulation of extended-release oral dosage forms targeting neuropathic pain and restless legs syndrome.

Application

• Pharmaceutical Active Ingredient (API) Intermediate: A key precursor in the synthesis of finished dosage forms of gabapentin enacarbil.
• Extended-Release Formulations: Enables the development of once-daily oral tablets for improved patient compliance in chronic conditions.
• Neuropathic Pain Management: Used in the production of medications for postherpetic neuralgia and diabetic peripheral neuropathy.
• Restless Legs Syndrome (RLS) Therapy: Serves as the active pharmaceutical component in treatments specifically indicated for moderate-to-severe RLS.
• Drug Delivery Research: Studied in academic and industrial labs for novel prodrug delivery systems and bioavailability enhancement.
• Reference Standard: Employed as an analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.

Basic Information

Item	Details
Product Name	Gabapentin Enacarbil Sodium Salt
CAS No.	912486-72-7
Molecular Formula	C16H27NNaO5
Molecular Weight	336.38 g/mol
Synonyms	XP13512 Sodium Salt; (1-{[(α-Isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexyl)acetic acid sodium salt; Gabapentin Enacarbil Na; Gabapentin Enacarbil Sodium; Sodium;2-{1-[(2-{[(2-methylpropanoyl)oxy]methoxy}-2-oxoethyl)carbamoyl]cyclohexyl}acetate
EINECS	Contact for details

Quality Control

Our Gabapentin Enacarbil Sodium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications suitable for pharmaceutical R&D and manufacturing. A Certificate of Analysis (COA) detailing results for identity, purity, residual solvents, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.