Description

Ganaxolone CAS NO 38398-32-2 is a synthetic neuroactive steroid and a positive allosteric modulator of GABAA receptors. This compound is of significant commercial and research interest due to its targeted mechanism of action in modulating neuronal excitability. It is primarily required by pharmaceutical research and development organizations, contract manufacturing organizations (CMOs), and academic institutions engaged in neuroscience and neuropharmacology studies.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of investigational neurotherapeutics.
• Neurological Disorder Research: Critical reference standard and tool compound for studying epilepsy, seizures, and related CNS conditions.
• Mechanism of Action Studies: Used in vitro and in vivo to investigate GABAA receptor pharmacology and allosteric modulation.
• Preclinical Development: Serves as a key material for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Process Chemistry & Analytical Development: Used as a standard for developing and validating synthetic routes and analytical methods (e.g., HPLC, GC).
• Regulatory Submissions: Supplied as a characterized compound for inclusion in regulatory filings (e.g., IND, NDA).

Basic Information

Product Name	Ganaxolone
CAS No.	38398-32-2
Molecular Formula	C22H36O2
Molecular Weight	332.52 g/mol
Synonyms	3α-Hydroxy-3β-methyl-5α-pregnan-20-one; CCD-1042; 3α-Methyl-5α-pregnan-3β-ol-20-one; (3α,5α)-3-Hydroxy-3-methylpregnan-20-one; Ganaxolone (USAN); ZT-1-73
EINECS	Contact for details

Quality Control

Our Ganaxolone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support regulatory requirements with comprehensive documentation. Certificates of Analysis (COA) detailing purity, related substances, residual solvents, and other critical parameters are available for every lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.