Description

1H-Benzimidazole-7-Carboxamide, 2-[(2S)-2-Methyl-2-Pyrrolidinyl]-, Hydrochloride (1:2) is a high-purity, chiral benzimidazole derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or a potential active pharmaceutical ingredient (API) building block, valued for its precise stereochemistry and functional group arrangement. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates targeting various disease pathways.
• Protease Inhibitor Research: Used in the development of inhibitors for enzymes like HCV NS3/4A protease or other serine proteases, given the benzimidazole scaffold's prevalence in this class.
• Kinase Inhibitor Development: Serves as a core structure or intermediate for designing selective kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology & Probe Synthesis: Employed in creating molecular probes to study biological processes and protein function.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of complex active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: The (S)-configured methylpyrrolidine moiety makes it a valuable chiral synthon for constructing molecules with defined stereocenters.

Basic Information

Product Name	1H-Benzimidazole-7-Carboxamide, 2-[(2S)-2-Methyl-2-Pyrrolidinyl]-, Hydrochloride (1:2)
CAS No.	912445-36-4
Molecular Formula	C14H19N4O·2HCl
Molecular Weight	347.25 g/mol (as hydrochloride salt)
Synonyms	(2S)-2-Methyl-1-(7-carbamoyl-1H-benzimidazol-2-yl)pyrrolidine dihydrochloride; 2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-7-carboxamide dihydrochloride; BILN 2061 Intermediate; BILN 2061 ZW; Ciluprevir Intermediate; (S)-2-Methyl-1-(7-carbamoyl-1H-benzo[d]imidazol-2-yl)pyrrolidin-1-ium chloride hydrochloride; UNII-9H13C9S6F2
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting identity, purity, and impurity profiles. We support development under cGMP guidelines as required for clinical trial material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.