Description

5-Trifluoromethoxy-1H-Benzimidazole is a high-value, fluorinated benzimidazole derivative, serving as a critical building block in advanced organic synthesis. This compound is prized for its unique trifluoromethoxy substituent, which imparts enhanced metabolic stability and lipophilicity to target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced fungicides and herbicides, where the trifluoromethoxy group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, leveraging its aromatic and heterocyclic structure.
• Chemical Biology Probes: Employed in the design of molecular probes and diagnostic agents due to its distinct chemical signature.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	5-Trifluoromethoxy-1H-Benzimidazole
CAS No.	911825-64-4
Molecular Formula	C8H5F3N2O
Molecular Weight	202.13 g/mol
Synonyms	5-(Trifluoromethoxy)-1H-benzimidazole; 1H-Benzimidazole, 5-(trifluoromethoxy)-; 5-Trifluoromethoxybenzimidazole; 5-(Trifluoromethoxy)benzimidazole; 911825-64-4; Benzimidazole, 5-trifluoromethoxy-
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethoxy-1H-Benzimidazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.