Description

2-(Piperazin-1-Yl)-1,3-Thiazole-4-Carboxylic Acid is a high-value heterocyclic building block and pharmaceutical intermediate of significant interest in modern organic synthesis. Its molecular architecture, featuring a piperazine-linked thiazole carboxylic acid, makes it a versatile scaffold for constructing complex molecules with targeted biological activity. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Chemical Research & Development: Serves as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Agrochemical Synthesis: Used in the research and development of new generation pesticides and herbicides that utilize thiazole and piperazine motifs.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for metal catalysis and in materials science research.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale API batches.

Basic Information

Product Name	2-(Piperazin-1-Yl)-1,3-Thiazole-4-Carboxylic Acid
CAS No.	911643-92-0
Molecular Formula	C8H11N3O2S
Molecular Weight	213.26 g/mol
Synonyms	2-(1-Piperazinyl)-4-thiazolecarboxylic acid; 4-Thiazolecarboxylic acid, 2-(1-piperazinyl)-; 2-Piperazin-1-yl-1,3-thiazole-4-carboxylic acid; 2-(Piperazin-1-yl)thiazole-4-carboxylic acid; 911643-92-0; Thiazole-4-carboxylic acid, 2-(piperazin-1-yl)-; 2-(Piperazin-1-yl)-1,3-thiazole-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(Piperazin-1-Yl)-1,3-Thiazole-4-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting compliance with agreed specifications. For research and cGMP applications, we offer tailored quality documentation to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.