Description

tert-Butyl 8-Amino-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, protected amine derivative of the isoquinoline scaffold, serving as a critical building block in advanced organic synthesis. This compound matters because it provides a versatile and reactive amine handle for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. Pharmaceutical researchers, agrochemical developers, and specialty chemical manufacturers need this intermediate for its role in creating novel compounds with potential therapeutic and functional properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and oncology.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging the bioactive isoquinoline core.
• Fine Chemical Synthesis: Serves as a versatile precursor for creating complex molecules in custom synthesis and process development.
• Chemical Biology & Proteomics: Employed as a building block for designing molecular probes, enzyme inhibitors, and tool compounds for biological research.
• Material Science: Potential monomer or functional additive in the synthesis of specialty polymers and advanced materials.
• Academic & Contract Research: Essential for medicinal chemistry programs and exploratory research in universities and CROs (Contract Research Organizations).

Basic Information

Product Name	tert-Butyl 8-Amino-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	910442-87-4
Molecular Formula	C14H20N2O2
Molecular Weight	248.32 g/mol
Synonyms	8-Amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 8-amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 2(1H)-Isoquinolinecarboxylic acid, 8-amino-3,4-dihydro-, 1,1-dimethylethyl ester; 8-Amino-THIQ-OtBu; Boc-8-Amino-THIQ; 8-Amino-1,2,3,4-tetrahydroisoquinoline-2-Boc; 910442-87-4
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Amino-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.