Description

2-Bromo-3-isocyanatothiophene is a highly reactive and versatile heterocyclic building block, specifically a thiophene derivative functionalized with both bromo and isocyanate groups. This dual functionality makes it a critical intermediate for the synthesis of complex molecules, enabling the construction of novel chemical architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and the development of advanced functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the thiophene scaffold for bioactivity.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for the production of specialty polymers, including polyurethanes and polyureas with unique thermal or electronic properties.
• Ligand & Catalyst Development: Employed in the creation of novel organometallic complexes and catalysts for asymmetric synthesis and coupling reactions.
• Chemical Biology Probes: Utilized to synthesize molecular probes for studying biological pathways and protein interactions due to its reactive isocyanate group.
• Dye & Pigment Intermediate: Functions as a building block for the development of advanced organic dyes and pigments with specific light-absorption characteristics.

Basic Information

Product Name	2-Bromo-3-isocyanatothiophene
CAS No.	910036-93-0
Molecular Formula	C5H2BrNO2S
Molecular Weight	219.04 g/mol
Synonyms	3-Isocyanato-2-bromothiophene; 2-Bromo-3-isocyanatothiophene; Thiophene, 2-bromo-3-isocyanato-; 2-Bromothiophene-3-isocyanate; 2-Bromo-3-thienyl isocyanate
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-isocyanatothiophene is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.