Description

5-Fluoro-1-(Triisopropylsilyl)Indole is a high-value, organosilicon-protected indole derivative, specifically engineered as a key synthetic intermediate. Its core value lies in providing a sterically shielded and reactive site for the controlled functionalization of the indole scaffold, enabling complex molecular construction. This compound is essential for researchers and manufacturers in pharmaceutical development and advanced organic synthesis, particularly for creating novel active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of fluorinated indole-based drug candidates, including potential kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Research: Used in developing novel fluorinated pesticides and herbicides, where the fluorine atom and indole core can enhance biological activity and environmental stability.
• Material Science: Serves as a precursor for organic semiconductors, liquid crystals, and photoactive materials due to its conjugated indole system and tailored solubility from the triisopropylsilyl (TIPS) group.
• Cross-Coupling Reactions: The TIPS-protected nitrogen allows for selective functionalization at other ring positions via palladium-catalyzed reactions like Suzuki-Miyaura or Buchwald-Hartwig amination.
• Directed Ortho Metalation (DoM): The fluorine atom acts as a directing metalation group, enabling precise substitution patterns on the indole ring for creating diverse chemical libraries.
• Fluorine Chemistry Research: A valuable substrate for studying the effects of fluorine substitution on the reactivity and electronic properties of heterocyclic compounds.

Basic Information

Product Name	5-Fluoro-1-(Triisopropylsilyl)Indole
CAS No.	908600-86-2
Molecular Formula	C17H26FNSi
Molecular Weight	291.48 g/mol
Synonyms	1H-Indole, 5-fluoro-1-[(1,1-dimethylethyl)dimethylsilyl]-; 5-Fluoro-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indole; 5-Fluoro-1-(t-butyldimethylsilyl)indole (common error/related compound); 5-Fluoro-1-TIPS-indole; 5-Fluoro-1-triisopropylsilylindole; 5-Fluoroindole, 1-TIPS protected; TIPS-5-Fluoroindole
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1-(Triisopropylsilyl)Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting standards for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate to maximize shelf-life stability. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.