Description

3-Iodo-5-Nitro-1H-Indole is a halogenated nitroindole derivative, a versatile and highly functionalized heterocyclic building block. Its unique structure, featuring both an iodine atom and a nitro group on the indole scaffold, makes it a critical intermediate for synthesizing complex molecules in medicinal chemistry and materials science. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel compounds with targeted biological or electronic properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in oncology, CNS disorders, and anti-infective research, leveraging the indole core's prevalence in bioactive molecules.
• Agrochemical Research: Used in the synthesis of new herbicides, fungicides, and insecticides, where the nitro and iodo groups allow for further functionalization to optimize activity.
• Organic Synthesis Building Block: Serves as a versatile precursor in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic substitutions due to the reactive iodine handle.
• Materials Science Precursor: Employed in the development of organic semiconductors, dyes, and photochromic materials, where the electron-withdrawing nitro group tunes electronic properties.
• Chemical Biology Probe Development: Utilized to create tagged molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	3-Iodo-5-Nitro-1H-Indole
CAS No.	908295-26-1
Molecular Formula	C8H5IN2O2
Molecular Weight	288.04 g/mol
Synonyms	5-Nitro-3-iodo-1H-indole; 3-Iodo-5-nitroindole; 1H-Indole, 3-iodo-5-nitro-; 908295-26-1; 3-I-5-NI; 5-Nitro-3-iodindol
EINECS	Contact for details

Quality Control

Every batch of 3-Iodo-5-Nitro-1H-Indole is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and mass spectrometry is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat and incompatible materials. Due to its light-sensitive nature, handling should be performed under subdued lighting where practical.

Specification

Item	Specification
Appearance	Yellow to brown powder or crystalline solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.