Description

Ethyl 4-(((tert-Butyldimethylsilyl)oxy)methyl)-2-chlorothiazole-5-carboxylate is a high-value, protected synthetic intermediate featuring a chlorothiazole core and a tert-butyldimethylsilyl (TBDMS) ether group. This compound matters as a critical building block in modern organic synthesis, enabling the precise construction of complex molecules where selective protection and functional group manipulation are required. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those containing thiazole heterocycles.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that leverage the bioactivity of the chlorothiazole moiety.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization, including cross-coupling reactions, hydrolysis, and deprotection sequences.
• Material Science: Potential intermediate for creating specialized polymers or organic electronic materials with unique properties.
• Academic & Contract Research: Essential reagent for methodological development and exploratory chemistry in university and CRO laboratories.

Basic Information

Product Name	Ethyl 4-(((tert-Butyldimethylsilyl)oxy)methyl)-2-chlorothiazole-5-carboxylate
CAS No.	907545-49-7
Molecular Formula	C13H22ClNO3SSi
Molecular Weight	335.92 g/mol
Synonyms	Ethyl 2-chloro-4-(((tert-butyldimethylsilyl)oxy)methyl)thiazole-5-carboxylate; 2-Chloro-4-(((tert-butyldimethylsilyl)oxy)methyl)thiazole-5-carboxylic acid ethyl ester; 5-Carbethoxy-2-chloro-4-((tert-butyldimethylsilyloxy)methyl)thiazole; TBDMS-protected 2-chlorothiazole ester; 907545-49-7
EINECS	Contact for details

Quality Control

Our production of Ethyl 4-(((tert-Butyldimethylsilyl)oxy)methyl)-2-chlorothiazole-5-carboxylate adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.