Description

(S)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. Its primary importance lies in its role as a key precursor in the synthesis of complex bioactive molecules, particularly in medicinal chemistry and drug discovery. This compound is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical suppliers focused on producing active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in the design and development of new therapeutic agents, particularly in central nervous system (CNS) and cardiovascular research.
• Asymmetric Synthesis: Serves as a versatile building block for constructing chiral molecules with high enantiomeric purity.
• Alkaloid Synthesis: A key precursor in the total synthesis of isoquinoline-based natural products and alkaloids.
• Peptidomimetics Development: Incorporated into the backbone of peptide-like compounds to enhance stability and bioavailability.
• Chemical Biology Probes: Used to create labeled or tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	(S)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid
CAS No.	905847-63-4
Molecular Formula	C₁₂H₁₅NO₄
Molecular Weight	237.25 g/mol
Synonyms	(3S)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (S)-6,7-Dimethoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; (S)-Tic(6,7-OMe)OH; (S)-1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinoline-3-carboxylic acid; (S)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (S)-DTIQ-3-COOH; (S)-3-Carboxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (S)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.