Description

1-Boc-5-Bromo-3-Hydroxymethylindole is a high-purity, protected indole derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex molecules, where the Boc (tert-butoxycarbonyl) group offers orthogonal protection for the indole nitrogen, and the bromo and hydroxymethyl substituents provide distinct handles for further functionalization. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting neurological disorders and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides due to its modifiable indole core.
• Material Science: Serves as a monomer or functional unit in the creation of specialized polymers and organic electronic materials.
• Academic & R&D: A valuable reagent for methodological studies in synthetic organic chemistry, including cross-coupling and protection/deprotection strategies.
• Peptidomimetics: Employed in the design and synthesis of indole-based peptidomimetics and protease inhibitors.
• Ligand Synthesis: Useful for constructing novel ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Boc-5-Bromo-3-Hydroxymethylindole
CAS No.	905710-14-7
Molecular Formula	C₁₄H₁₆BrNO₃
Molecular Weight	326.19 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-5-bromo-3-(hydroxymethyl)indole; 5-Bromo-3-(hydroxymethyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 5-bromo-3-(hydroxymethyl)-1H-indole-1-carboxylate; 1-Boc-5-bromoindole-3-methanol; Boc-5-Br-3-CH2OH-indole; 905710-14-7; 1-Boc-5-bromo-3-hydroxymethyl indole
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Bromo-3-Hydroxymethylindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.